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| | Cosmetic Raw Materials (10th May 23 at 2:05am UTC) | | Cosmetic Raw Materials 1. What is Azelaic acid powder?
Azelaic acid is a classic medicinal ingredient. Whenever an ingredient is associated with a drug or disease treatment, there is a lot of literature evidence. Like retinoic acid, like niacin (vitamin B3), like vitamin C. But azelaic acid is a niche player in the skincare industry. In fact, it is a safe, effective and good medicine for acne and rosacea with few side effects. It is also very effective for pigmented diseases such as melasma and melanoma.
Azelaic acid, also known as azelaic acid, is an all-around ingredient that can sterilize, anti-inflammatory, control oil, and prevent skin keratinization. Among all functions, sterilization is the core effect. Azelaic acid can inhibit the protein synthesis of microorganisms, and can kill Propionibacterium acnes and Staphylococcus epidermidis, which is more suitable for redness and acne.
Azelaic acid is a relatively versatile ingredient, which has some effects on oil control, antibacterial, anti-inflammatory, and whitening. It is commonly used in the treatment of acne skin, and it is relatively safe and mild.
2.How is azelaic acid commonly used?
Azelaic acid has an inhibitory effect on the activity of tyrosinase, whitening and freckle removal, and the effect is equivalent to 1/10 of hydroquinone. . Azelaic acid is a good stabilizer for the emulsion system, and the salts of azelaic acid have self-emulsifying function, and it can be used in soap to avoid the cracking of the soap body surface. Azelaic acid has antibacterial properties, and can be used not only as a preservative for food and cosmetics, but also for oral hygiene products to prevent dental caries; it has significant penetration in the skin surface, and the penetration efficiency is several times that of dimethyl sulfoxide. In the emulsion system commonly used in cosmetics, the efficiency of azelaic acid to carry active ingredients into the cortex is higher than that of dimethyl sulfoxide, and 43% to 64% of the drugs can penetrate into the cortex, while only 1% to 2% of dimethyl sulfoxide is used. % (dimethyl sulfoxide is not suitable as a penetrant in cosmetic products), it can be used as a penetrant in lotions and ointments to treat more serious skin diseases, such as acne and skin disorders; azelaic acid can balance male hormones and can prevent Male hormonal alopecia caused by strong endocrine in men, and can stimulate hair growth at the same time, the dosage is 0.01%~1%.
3.The specific role of azelaic acid powder
鈶犮€€anti-oxidation
Azelaic acid gently exfoliates, it helps to unclog pores and refine the skin's surface. Azelaic acid reduces skin sensitivity and has antioxidant properties. It is found naturally in cereals like barley, wheat, rye and.
鈶°€€Blemish and acne scar reduction
Studies have shown that azelaic acid can significantly reduce the appearance of skin blemishes, lighten dark spots such as acne marks, refine the skin's surface, and even out skin tone.
鈶€€Treat rosacea
146 patients with papulopustular rosacea were reported, with an average age of 49 years and a disease duration of 5.5 years. A multicenter randomized double-blind trial was used. Among them, 77 patients received azelaic acid cream, and another group of 39 patients was compared with placebo. Topical application 2 times a day for 3 months. Results: About 73% of the patients in the azelaic acid cream group had improved inflammation, but only 50.6% in the control group; the erythema severity score was reduced by an average of 47.9% in the azelaic acid group and 37.9% in the control group. comparison, the difference is significant
鈶ｃ€€ Antibacterial
Can be used as food preservatives. Use in mouthwash is beneficial to the prevention and treatment of dental caries, and use in soap can avoid the cracking of the surface of the soap body
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5.Pharmacological mechanism of azelaic acid
The pharmacological effects of azelaic acid can be summarized into the following five aspects:
(1). Directly inhibit and kill bacteria on the skin surface and in the hair follicles, and eliminate pathogens;
(2). Competitively inhibit the enzymatic process of producing dihydrotestosterone and reduce excessive skin oil caused by dihydrotestosterone factors;
(3). Inhibit the production and function of active oxygen free radicals, which is beneficial to anti-inflammatory;
(4). Reduce the synthesis of filamentous keratin and prevent excessive keratinization of hair follicles;
(5). Destroy cell mitochondrial respiration and inhibit cell synthesis, thereby inhibiting cell proliferation.
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8.WHY CHOOSE US?Cosmetic Raw Materials
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